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Feature Metaplasia Dysplasia i) Definition Change of one kind of epithelial or mesenchymal Disordered mobile development, may be cell to a different sort of adult epithelial or mesen accompanied with hyperplasia or metaplasia chymal cell ii) Types Epithelial (squamous, columnar) and Epithelial solely mesenchymal (osseous, cartilaginous) iii) Tissues affected Most generally affects bronchial mucosa, uterine Uterine cervix, bronchial mucosa endocervix; others mesenchymal tissues (cartilage, arteries) iv) Cellular adjustments Mature cellular growth Disordered cellular growth (pleomorphism, nuclear hyperchromasia, mitosis, lack of polarity) v) Natural history Reversible on withdrawal of stimulus May regress on elimination of inciting stimulus, or could progress to higher grades of dysplasia or carcinoma in situ cells such as neurons and myocytes. 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