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Risk of bias Bias Authors� judgement Support for judgement Random sequence technology (choice Unclear danger Not described bias) Allocation concealment (choice bias) Unclear threat Not described Blinding of individuals and personnel Low danger Participants and personnel blinded using (performance bias) placebo All outcomes Blinding of end result evaluation (detection Low danger Outcome assessors blinded utilizing placebo bias) All outcomes Incomplete end result data (attrition bias) Unclear threat Published information unavailable All outcomes Selective reporting (reporting bias) Unclear danger Published information unavailable L-ornithine L-aspartate for prevention and therapy of hepatic encephalopathy in people with cirrhosis (Review) 66 Copyright � 2018 The Cochrane Collaboration. As monotherapy, alprostadil is the preferred vasoactive agent; however, combination therapy with the opposite vasoactive medicine (bimix and trimix) can both improve efficacy or reduce side effects. 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