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Grade Clinical Criteria Grade Clinical Criteria 0 No symptoms four Skin blanched, translucent 1 Skin blanched Skin tight, leaking Edema 1 inch in any course Skin discolored, bruised, swollen Cool to touch Gross edema 6 inches in any direction With or with out ache Deep pitting tissue edema 2 Skin blanched Circulatory impairment Edema 1 to six inches in any path Moderate–severe ache Cool to the touch In?ltration of any quantity of blood product, With or without pain irritant or vesicant three Skin blanched, translucent Gross edema 6 inches in any course Cool to the touch Mild–moderate pain Possible numbness (From Infusion Nurses Society medicine 93 7338 order cabgolin 0.5mg amex. The studies consist in two years feeding or gavage experiments involving groups of fifty male and female Fischer -344/N rats and B6C3F1 mice (Haseman et al, 1984, 1987). 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