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O-1 O-2 Clinical Overview Vesiculobullous DiseasesпїЅcontпїЅd Disease Clinical Features Cause Signifcance Herpes Simplex Infections Varicella Painful pruritic vesicles and Varicella-zoster virus Self-limited; recovery unevent ulcers in all phases on trunk ful in several weeks; vaccine and face; few oral lesions; out there widespread childhood disease Herpes zoster Unilateral a number of ulcers pre Reactivation of varicella-zoster Self-limited; could have a pro ceded by vesicles distrib virus longed, painful course (post uted along a sensory nerve herpetic neuralgia); seen in course; very painful; usually debilitation, trauma, neopla on trunk, head, and neck; sia, and immunodefciency uncommon intraorally; adults Hand-foot-and-mouth disease Painful ulcers preceded by Coxsackie viruses пїЅ (A16, Self-restricted; recovery unevent vesicles on arms, toes, and others) (enterovirus family) ful in about 2 weeks oral mucosa; normally in youngsters; communicable; oro-fecal transmission; rare Herpangina Multiple painful ulcers in poste Coxsackie viruses types A1, 6, Self-restricted; restoration unevent rior oral cavity and pharynx; eight, 10, 22, others; (enterovi ful in less than a week lesions preceded by rus household) vesicles; kids most com monly affected; seasonal incidence; rare Continued Clinical Overview O-three пїЅ Figure 1 Primary herpes simplex an infection spasms pregnancy after tubal ligation buy colospa 135mg with mastercard.